Study of Biological Properties of Cell Lines Transformed by Herpes Simplex Virus

QIU Su-Ying; CAO Zong-Li; DONG Jie-De; CHEN Chen-Hua; ZENG Li; SONG Yuan-Di; XU Xiu-Ping

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Virologica Sinica, 03 (1) : 27, 1988

Review

Study of Biological Properties of Cell Lines Transformed by Herpes Simplex Virus

QIU Su-Ying, CAO Zong-Li, DONG Jie-De, CHEN Chen-Hua, ZENG Li, SONG Yuan-Di, XU Xiu-Ping

Department of Microbiology
Shandong Medical University
Jinan

Correspondence:

(674.34KB)

Abstract

The biological properties of three cell lines transformed by HSV-2 were investigated. The results indicate that the transformed cell lines possess the following characteristies:(1) chromosomal abnormalities; (2) reduce of requirement for serum factor; (3) rapid growth; (4) colony formation in soft agar; (5) increase of agglutination by Con Aand(6) induction of malignant tumor in nude mice These strongly suggest that the transformed cells are neoplastic.

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Published online: 5 Mar 1988