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Virologica Sinica, 03 (2) : 148, 1988
Review
Assay for HSV-Induced Deoxythymidine Kinase and Its Application to Antiviral Compound Study
Department of Microbiology
Tianjin Medical College
Tianjin
 Correspondence:
(275.38KB)  
Abstract
An assay for herpes simplex virus type 1 and 2 induced deoxythymidine (dTK) was described by using ~(125)Ⅰ-UdR as substrate. The assay was also used for detecting the sensitivity of HSV-1 and HSV-2 induced dTK to DHPG. The result showed that sensitivity of viral dTK to DHPG was higher than HeLa cell-dTK s. In addition, we thought that toxicity of DHPG to host cells might be related to the low sensitivity of cell-dTK to DHPG.
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  Published online: 5 Mar 1988
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