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Virologica Sinica, 03 (3) : 265, 1988
Transformation of Human Embryonic Lung Cells by Ultraviolet Irradiation Inactivated Herpes Simplex Virus Type 2
Department of Microbiology
Shandong Medical University
Three transformed human cell lines were obtained after infection of human embryo lung cells with ultraviolet irradiation inactivated HSV-2. The transformed cells appear polygonal resembling epithelial cells. They are morphologically compatible with neoplastic cells, Chromosome examination showed hyperdiploid karyotype. In vitro, afftcr eonfluency of monolayers they continue to grow into pyramidal masses indicating loss of contact inhibition. Indirect immunoenzymatic test revealed the presence of HSV antigen...
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  Published online: 5 Sep 1988
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