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Virologica Sinica, 03 (3) : 272, 1988
Review
Studies on Monoclonal Antibodies to Hepatitis A Virus
Departmynt of Viral Disease Control
Health and Antiepidemic Centre of Sichuan Province
Chengdu
 Correspondence:
(612.57KB)  
Abstract
Three strain hybridomas (AG3, AD2, AE8) were developed by cell fusion technique. They secreted stably MeAbs against HAV with the titer of 1: 128000—1: 1024000 in ascites fluid by ELISA. All of these McAbs are of positive reaction on HAV derived from patient s stools and cell culture, and this reaction can be inhibited by human anti HAV positive sera. The results of cell neutralization test and cross-blocking ELISA show that AE8 McAb is able to neutralize HAV infectivity, and that these McAbs recognize diffe...
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  Published online: 5 Sep 1988
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