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Virologica Sinica, 03 (3) : 272, 1988
Studies on Monoclonal Antibodies to Hepatitis A Virus
Departmynt of Viral Disease Control
Health and Antiepidemic Centre of Sichuan Province
Three strain hybridomas (AG3, AD2, AE8) were developed by cell fusion technique. They secreted stably MeAbs against HAV with the titer of 1: 128000—1: 1024000 in ascites fluid by ELISA. All of these McAbs are of positive reaction on HAV derived from patient s stools and cell culture, and this reaction can be inhibited by human anti HAV positive sera. The results of cell neutralization test and cross-blocking ELISA show that AE8 McAb is able to neutralize HAV infectivity, and that these McAbs recognize diffe...
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  Published online: 5 Sep 1988
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