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Virologica Sinica, 05 (3) : 259, 1990
Morphology, Distribution and Its Signification of Intrahepatic HBV DNA in Liver Disease: A Study by in Situ Hydridization
Clinical Immunology Research Unit
Department of Infectious Diseases
Tongji Hospital
Tongji Medical University
Wuhan 430030
A biotin-labeled DNA probe specific for hepatitis B virus(HBV)nucleotide sequences was hybridized in situ to liver tissue of 129 cases with liver disease. It was found that HBVDNA was predominantely visualized in cytoplasm of hepatocytes in three ways,cytoplasmic compact pattern,discrete pattern abd inclusion pattern. Its distribution in parenchyma within the section of specimens may be defined as lobular, focal and spotty. The detection of intrahepatic HBVDNA depanded on two factors at least in present stu...
  Published online: 5 Sep 1990
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