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Virologica Sinica, 06 (1) : 33, 1991
Anti-SRSV Activity of Antisense Oligodeoxynucleotides
Department of Biophysics
Shanghai Medical University
Shanghai 200032 Shanghai Institute of Biochemistry
Academia Sinica
Shanghai 200031
Synthesized antisense oligodeoxynucleotides, including modified and unmodified, homo- and hetero-forms, were tested for their ability to inhibit mouse SRS virus-induced cellular multiplication, the formations of colonies of SRSV-infected cells and XC syneytia and RT activity. All oligomers were found to be active. Preminary studies of acute toxicity in mice showed that his compound to be nontoxic at high levels It is suggested that different classes of oligonucleotides may inhibit virus replication by diffe...
  Published online: 5 Mar 1991
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