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Virologica Sinica, 07 (2) : 134, 1992
Preliminary Report of Cell Culture of Hepatitis E Virus
Institute of Microbiology and Epdemiology
Academy of Military Medical Sciences
Beijing 100071
Hepatitis E virus(HEV) was isolated in human embryomic lung cell inoculated with liver tissue suspension from an HEV-infected rhesus monkey, Slight cytopathic effect(CPE) appeared at the 27th day after 4 blind passages of viruses in cell culturs to at 17th day after 7 passages. Low amounts of 27—34nm virus-like particles(VLPs) in cell cultures were visualized by immunoelectronmicroseopy(IEM). 2 of 3 rhesus monkeys inoculated with 20ml of pool of cell cultures from 4 to 7 passages developed significant eleva...
  Published online: 5 Jun 1992
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