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Virologica Sinica, 08 (1) : 20, 1993
Review
Pathogenicity and Immunogenicity of Attenuated Japanese Encephalitis Vaccine (SA_(14)-14-2) in Immune-Inhibited Mice
Notional Institute lor Conlro1 掳f Pharmaceutical and Biological Products
Beijing 100050
 Correspondence:
(115.89KB)  
Abstract
In this study, three-week-old mice, 12—14g, were treated by cytoxan three times. They were then injected subcutaneousiy with SA_(14)-14-2 live vaccine, no mouse was killed by the attenuated virus. When the immune-inhibited mice were immunized with the attenuated live vaccine and the inactivated JE vaccine, they exhibited different immune responses to the both vaccines. Those immunized with the attenuated live virus showed better protective effect (protective rate 56—80%)against JE virulent virus challenging...
  Published online: 5 Mar 1993
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