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Virologica Sinica, 08 (3) : 213-217, 1993
Studies on Liver Biopsy of Epidemic Hemorrhagic Fever by in Situ Hybridization and Immunohistochemistry
Bethune International Peace Hospital
The EHF RNA and its G2 antigen were detected by in situ hybridization and immunohistoche- mistry on liver biopsy specimens of 25 cases of EHF patients among whom 23 are postive. Our results indicated that the degeneration and the single hepatocyte necrosis were due to the EHF virus invading hepatocytes directly and replicating in their cytoplasm; the local hepatocyte necrosis may be a kind of ischemia infarct which was mainly because of micro-circulation disturbance owing to the narrow of heaptocellular si...
  Published online: 5 Sep 1993
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