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Virologica Sinica, 08 (3) : 218-225, 1993
Experimental Infection of Hemorrhagic Fever with Renal Syndrome Virus in Mice and Viral Antigen Localization in Mouse Lymphocyte Subpopulations
Department of Infectious Diseases
Tangdu Hospital
The Fourth Military Meical University
Xi an
710038 Institute of Virology
The Notional Academy of Prevention
Double-immunoctytochemistry and double-immunoelectron microscopy were applied to investigate the pathogenesis and virus localization in cyclophosphamide-treated adult and suckling BALB/c mice af- ter the infection of hemorrhagic fever with renal syndrome virus. It was found that, after the infec tion, immunologically immature or deficient mice developed disease and died regularly, while normal adult mice showed only a subelinical infection. The major difference of virus localization between the diseased and...
  Published online: 5 Sep 1993
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