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Virologica Sinica, 10 (1) : 25, 1995
Review
Characterization of Epstein—Barr Virus Gene Detected in Nasopharyngeal Carcinoma
Shanghai Second Medical University
 Correspondence:
(173.56KB)  
Abstract
We analysed the BamHl EZ fragment of Epstein—Barr Virus in 21 cases of tissues from nas opha.ry'ngeal c~rcinoma(NPC)by polymerase chain reaction(PCR)and,r~quence analysis.The 2.99kb deletions within lhmHl EZ fragment were found in 1 1 sfm1DIes,the deletions wei'~similar to those 0f Raji EBV which is latent in Burkitt s lymphoma.The BZLF1 gene of EBV locates within Bam HI EZ fragment an d has an impor~nt role in reproduc~ve cycle of EBV.Two point m utatioas were also found in the first exon of BZLFt gcne from a sam ple analyzed ,com pared to the standard B9S.8 EBV. The m uta tions above may affect the latency~disrupting function of Epstein Barr Virus
  Published online: 5 Mar 1995
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