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Virologica Sinica, 10 (1) : 25, 1995
Characterization of Epstein—Barr Virus Gene Detected in Nasopharyngeal Carcinoma
Shanghai Second Medical University
We analysed the BamHl EZ fragment of Epstein—Barr Virus in 21 cases of tissues from nas opha.ry'ngeal c~rcinoma(NPC)by polymerase chain reaction(PCR)and,r~quence analysis.The 2.99kb deletions within lhmHl EZ fragment were found in 1 1 sfm1DIes,the deletions wei'~similar to those 0f Raji EBV which is latent in Burkitt s lymphoma.The BZLF1 gene of EBV locates within Bam HI EZ fragment an d has an impor~nt role in reproduc~ve cycle of EBV.Two point m utatioas were also found in the first exon of BZLFt gcne from a sam ple analyzed ,com pared to the standard B9S.8 EBV. The m uta tions above may affect the latency~disrupting function of Epstein Barr Virus
  Published online: 5 Mar 1995
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