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Virologica Sinica, 10 (1) : 48, 1995
In situ Hybridzafion Detection of Hantavirus M and S RNA in Autopsy Tissues of the Patients with Hemorrhagic Fever with Renal Syndrome
The 4th Medical University
In situ hybridization was used for detection of hantavirus RNA in the tissues of 1 9 cadavers with hemorrhagic fever w ith renal syndrome (HFRS) collected from different HFRS endemic foei in China. Viral RNA wiLq detec ted in a11 the 1 9 cases. It was mainly located in epithelial or parenchymal ca lls of various organs with the positive cells in scattered,focal or wide distribution in the eases from Shaanxi and Shenyang,and in vascular endothelial cells of various organs as well as part of pa renchy real cells in the cases from Jiangxi,while in the case from Guangzhou.it was positive in focal necrotihe,alveolar sa ,renal interstit~l va u1a【urcs,etc.V RNA mainly I.oc,~liz.oci in the cytoplasms with ‰ rse grarlales orfine powdery specking staining.to a lesser extent also over cellular nucleus~ Besides.the po r,itive hybridization signals were also demonstrated in extrace linlar space~and oil RBC in some tissues and cases.The results suggest that hantavirus infection in human wz~ls ImntroDic and pred ilec tion for epithelial or endothelial cells an d th e latter may be caused by the difference of strain or scrotype of mfec ted virus,and may result to the variance in nathogenesis of HFRs.
  Published online: 5 Mar 1995
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