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Virologica Sinica, 10 (2) : 141, 1995
A Skewed Light Chain Isotype Expression and B-Cell Clonal Dominance of Anti-HCV Response in Hepatitis C Virus Infection
Institute of microbiogy and Epidemiology
Academy of Militarg Medical Sciences
Beijing 100071School of Public Health
Beijing Medical University
Beijing 100083
In antigen capture ELISA in which HCV peptides NS4 CP1 and CP2 derived from Hcv NS4and core gene region,respectively,were used as solid-phase antigens was developed to detect the differences in light chain isotype expresslion of anti-HCV antibodies. Antibodies in 65 sera of HCV infectedprofessional blood donors against HCV NS4,CP1 and CP2 were characterized by a skewed light chainisotype expression. Sixty-three out of the 65 donors(96.9%)showed at least one of the three anti-HCV antibodies skewed from the no...
  Published online: 5 Jun 1995
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