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Virologica Sinica, 10 (2) : 141, 1995
Review
A Skewed Light Chain Isotype Expression and B-Cell Clonal Dominance of Anti-HCV Response in Hepatitis C Virus Infection
Institute of microbiogy and Epidemiology
Academy of Militarg Medical Sciences
Beijing 100071School of Public Health
Beijing Medical University
Beijing 100083
 Correspondence:
(176.19KB)  
Abstract
In antigen capture ELISA in which HCV peptides NS4 CP1 and CP2 derived from Hcv NS4and core gene region,respectively,were used as solid-phase antigens was developed to detect the differences in light chain isotype expresslion of anti-HCV antibodies. Antibodies in 65 sera of HCV infectedprofessional blood donors against HCV NS4,CP1 and CP2 were characterized by a skewed light chainisotype expression. Sixty-three out of the 65 donors(96.9%)showed at least one of the three anti-HCV antibodies skewed from the no...
  Published online: 5 Jun 1995
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