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Virologica Sinica, 10 (3) : 197, 1995
Review
Further characterization of viral inclusion body in the autopsy tissues of patients suf- fered from hemorrhagic fever with renal syndrome
Dep. of Pathology,Institute of Neurosciences,the Fouth Military Medical Universitry,Xi'an 710032
 Correspondence:
(214.42KB)  
Abstract
Immunocytochemistry and in situ hybridization were performed on the autopsy tissues of 39 fetal cases of patients with hemorrhagic fever with renal syndrome to search for viral in-clusion body(IB)and study its antigenic and nucleic acid characters.The tissues with IB were further observed by electron and immunoelectron microscope.Immunohistochemically,IB,a coarse cytoplasmic granule. was positive for anti-nucleocapsid and hemogglutinin antibody,but negative for anti-evelope protein antibody.It was found in 20 of 39 cases including 10 cases died at hypotensive phase,9 cases died at oliguric phase and 1 case died at diuretic phase of HFRS,and distributed in the renal distal convoluted and collecting tubular cells,hepatocytes mucosal and glandular epithelial cells of respiratory tract,alveolar sacs,gastroin-testinal tract,tonsil,salivary gland,pallcreas,prostate gland and pituitary gland,and seminif-erous epithelial cell of testis,etc.The similar granules with viral RNA positive were observed only in a small
  Published online: 5 Sep 1995
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