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Virologica Sinica, 10 (4) : 273, 1995
The study on adaptation of Japanese encephalitits virus in Veto cells
Beijing Biological Product Institute
3 strain of Japanese Encephalitis(JE)virus was adapted in Vero cells for 27 passages;Nosignlficant changes were found on virus titre and CPE after adaptation,but the immunogenicitywas getting weaker after 10 passages.The immunogenicity weakened could be recovered partlallyby repassag ing the V ero-cells adapted virus in mouse brain,Less than 10 passages of ad aptedviru s growing in Vero cells could be used as seed virus for prod uction of JE vaccine instead ofvirus prepared from mouse brain.U sing the ad apted virus for vaccine production could be easierto avoid the contamination of extraneous agents com pared with using the virus from mouse brain.
  Published online: 5 Dec 1995
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