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Virologica Sinica, 10 (4) : 309, 1995
Cloning and sequencing of pSTY28 DNA fragment of human herpesvirus-6
Department of Microbiology,Shanghai Medical University,shanghai 200032
This report confirms the sequence of pSTy 28 fragment of HHV-6.We jave determined thecomplete nucleotide sequence,The sequence data have revealed open reading frame(ORF)of 2414 nucleotides encoding a ribonucleotide reductase (RiR) protein of 805 amino acids and 1100nucleotides encoding a P41 protein,To examine the relatedness of RiR protein with those of otherherpesvirus,we compared their amino acid Sequence in pairwise combination,Interestingly,RiRORF of HHV-6 has shown to have the highest amino acid humology with the RiR of HCMV.The optimized score reaches 475.Biochemical analvsis of RiR has ind icated the active site ofthioredoxin ontaining two cysteins separated by two amino acids.This sequence was found onlyonce in the E.coli,HSV-2,EBV and mouse RiR protein,but we did not find it in the HHV-6and HCMV RiR protein.Those data support Esftathiou′s view that HHV-6 belongs to betaherpes viruses.
  Published online: 5 Dec 1995
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