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Virologica Sinica, 11 (4) : 348, 1996
Pharm acodynam ics Studies of Alternanthera philoxeroides Griseb in Oral for EHFV Infection in Suckling Mice
Virus Research Institute,Hubei Medical University,Wuhan 430071Hubei Traditional Medical College.Wuhan 430060
Antiviral effect of Alternanthera philoxeroides Griseb(APG)was studied in oral for epi-demic hemorrhagic fever virus(EHFV)infection in suckling mice.The APG dosages of A,BandC groups were 5mg/(g·d),7.5mg/(g·d)and 10mg/(g·d),respectively. The results showedthat the survival rate of A,B and C group were 80.0%,72.2% and 40.0%,the means time day(MTD)were 56.5±0.9, 53.5±1.1 and 41.5±2.7 day,respectively.The survival rate and MTD were 0.0% and 26.3±0.8 day in untreated viral control group.The antiviral effect of theAPG was similar with the ribavirin.This indicated that the APG was effective in treatment of epidemic hemorrhagic fever.
  Published online: 5 Dec 1996
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