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Virologica Sinica, 12 (3) : 244, 1997
Specific binding of hepatitis C virus to the Fc fragment of IgG molecules
卫生部上海生物制品研究所 DepartmentofInternalMedicine TheUniversityoflowaCollegeofMedicine lowaCity52246 U.S.A
Affinity- capture PCR method was adapted to study the interaction between hepatitis C virus (HCV) and human IgG, and demonstrated that HCV bound IgG and Fc fragment but not Fab fragment, The binding could be inhibited cometitively by Fc fragment but not Fab fragment. Meanwhile, pre -mccubation with HCV - RNA negative plapa did not inhibit subsequent binding of HCV to Fc fragment, further confirmed that this binding is just between HCV particles and Fc fragment, The results demonstrated an interaction betwee HCV and IgG, and gave a new explanaion by which HCV may trigger immune complex disease and the chronic trend of hepatitis C.
  Published online: 5 Sep 1997
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