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Virologica Sinica, 13 (1) : 45, 1998
The Inhibitory Effects of Enduracidin on Hepatitis B Virus in vitro
School of Pharmacy,Shanghai Medical Universlty,Shanghai 200032
Enduracidin was studied for its ability to inhibit Hepatitis B Virus DNA, HBsAg and HBeAg secreted by a HBV transfected cell line (HepG The result showed that IC 50 (the drug concentration that inhibits HBsAg or HBeAg secretion by 50%)was 27μg/mL and 34μg/mL respectively, theraputic index (TI) was 5.9 and 4.6. Enduracidin at the concentration of 50μg/mL inhibited 56.8% of the production of free HBV DNA in the Cells.
  Published online: 5 Mar 1998
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