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Virologica Sinica, 13 (2) : 182, 1998
Sequencing of a cDNA fragment of NS5A region of the defective hepatitis C virus
Department of Microbiology,Second Military Medical University.Shanghai 200433
Sensitive and specific anti HCV diagnostic kits are very important for preventing of the transmission of hepatitis C virus. Adding HCV NS5A antigen in diagnostic kits may increase the sensitivity of diagnostic reagents. The result of sequencing of NS5A cDNA fragment showed that it shares over 90% nucleotide acid and amino acid homology with HCV BK etc., so the isolate of this study belongs to HCV II. Besides, a mutation at 411nt in NS5A segment, which created a stop codon TGA in the reading frame was found, indicating that the isolate might be a defective virus. Perhaps the defective virus causes the persistent infection of HCV.
  Published online: 5 Jun 1998
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