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Virologica Sinica, 13 (4) : 311, 1998
Evaluation of antiviral effect of Polygonum cuspidatum water extract with a model of murine ac- quired immunodeficiency syndrome
The effect of Polygonum cuspidatum water extract (PCWE) on C57BL/6 mice infected with LP BM5 murine leukemia virus (MuLV) was investigated taking spleen index, viral antigen positive cell, serum IgG level and ConA response as parameters. It is demonstrated that PCWE can partly inhibit LP BM5 MuLV induecd splenomegaly, immunodeficiency and viremia of C57BL/6 mice.Antiviral effect of PCWE is more effective before or at the same time of virus inoculation than after virus inoculation. It indicates that the earlier treatment, the better. Continual treatment can partly improve splenomegaly and ConA response of infected mice, but the inhibition of PCWE on hypergrmmaglobulinemia of infected mice is non persistent.
  Published online: 5 Dec 1998
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