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Virologica Sinica, 14 (1) : 52-57, 1999
Different Nueleotide Sequences within One of Hepatitis B Virus Clones Patient
Huadong Research Institute for Medical Biotechnics,Nanfing 210002
The HBV HBsAg coding region of a hepatitis B patient was analyzed by PCR amplification, bacteriophage cloning and nucleotide sequencing. It was showed that among different clones from the same patient there were point mutations and these different nucleotide changes were not resulted from the methodologies. It is concluded that there are polymorphic HBV genomes within the same hepatitis B patient
  Published online: 5 Mar 1999
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