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Virologica Sinica, 15 (1) : 8-10, 2000
Study on Indeterminate HBsAg Samples
Dept of Hepatitis,National Institute 
for the Control of Pharmaceutical and Biological Products.Beijing 100050,China
Thirteen indeterminate HBsAg samples were tested with 21 sorts of HBsAg kits, anti HBs and anti HBc kits. HBV DNA was detected with nested PCR. The results showed that all of HBsAg kits can not easily detected HBsAg from some HBV DNA positive samples. It indicated that HBsAg concentration may be lower or HBV may be S mutants in those samples. So it is necessary to improve the sensitivity of HBsAg and to develop the diagnostic kit to detect HBV S mutants.
Key Words: HBsAg;  S gene;  mutant;  Diagnostic kit
  Published online: 5 Mar 2000
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