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Virologica Sinica, 15 (3) : 209-213, 2000
Four Kinds of EBV-Antisense Oiigodeoxynucleotides Effect on Proliferation of EBV Containing SUNE-1 Cell Line
Department of Bioclwmistry, Sun yat-sen 
University of Medical Sciences,Guangzhou 510089,China
Poorly differentiated nasopharyngeal carcinoma (SUNE 1) cell line was cultured with Epstein Barr virus (EBV) BHRF1, DNase, thymidine kinase (TK) and nuclear antigen 1 (EBNA1) antisense oligodeoxynucleotide (ASO) for 48 h respectively. Inhibited proliferation of SUNE 1 was only observed in the absence of fetal calf serum (FCS) and exposed to EBV BHRF1 ASO. The results from electron microscopy and agarose gel electrophoresis indicated that apoptosis only appeared in SUNE 1 cells exposed to BHRF1 ASO and absence of FCS. The other 3 kinds of EBV ASOs had not the similar effects at the same concentration.
  Published online: 5 Sep 2000
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