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Virologica Sinica, 15 (4) : 342-345, 2000
A Study on the Relation between Changes of lnterleukin and Receptor in Serum in Patients with Chronic Hepatitis B and Action of Treatment with IFN.a
Department of Infectious Disease, Union Hospita1,Tongii Medical University.Wuhan 430022.China
Objective\ To study the relationship between the changes of Interleukin and Receptor in serum of patients with chronic hepatitis B (CHB) before and after Interferon α (IFN α) treatment and expression of HBV marker. Methods: Enzyme liked immunosorbent assay (ELISA) were performed in 25 patients with CHB to determine levels of IL 6\, IL 2\,TNF α\, IL 8\, sIL 2R in serum. Results: Our date showed that the IL 6 level in response group after IFN α treatment was significantly lower than that befor (P<0.05). The level of IL 2 in unresponse group after IFN α treatment was significantly decreased, but the level in response group was significantly increased (P<0.01), but the serum sIL 2R level in patients with response was significantly decreased (P<0.01). The TNF α level in both response and unresponse group after IFN α treatment was significantly decreased (P<0.01), but the serum IL 8 level was increased. Conclusion\ The results suggest that HBV replication in patients with CHB could be also affected
  Published online: 5 Dec 2000
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