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Virologica Sinica, 15 (4) : 342-345, 2000
Review
A Study on the Relation between Changes of lnterleukin and Receptor in Serum in Patients with Chronic Hepatitis B and Action of Treatment with IFN.a
Department of Infectious Disease, Union Hospita1,Tongii Medical University.Wuhan 430022.China
 Correspondence:
(128.65KB)  
Abstract
Objective\ To study the relationship between the changes of Interleukin and Receptor in serum of patients with chronic hepatitis B (CHB) before and after Interferon α (IFN α) treatment and expression of HBV marker. Methods: Enzyme liked immunosorbent assay (ELISA) were performed in 25 patients with CHB to determine levels of IL 6\, IL 2\,TNF α\, IL 8\, sIL 2R in serum. Results: Our date showed that the IL 6 level in response group after IFN α treatment was significantly lower than that befor (P<0.05). The level of IL 2 in unresponse group after IFN α treatment was significantly decreased, but the level in response group was significantly increased (P<0.01), but the serum sIL 2R level in patients with response was significantly decreased (P<0.01). The TNF α level in both response and unresponse group after IFN α treatment was significantly decreased (P<0.01), but the serum IL 8 level was increased. Conclusion\ The results suggest that HBV replication in patients with CHB could be also affected
  Published online: 5 Dec 2000
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