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Virologica Sinica, 16 (1) : 11-14, 2001
Research Article
HSP72.1ike Immunoreactivities in the Brains of M ice Experimentally Infected with Hantavirus
Department of Pathology.Forth Military Medical University,Xi'an 710032,China
Sueking mice.2~3 day after birth,were intraperitoneally inoculated with 0 O5mL F1M lIl
0f Chen Strain Hantaan virus At different time point after inoculation,the brains were taken,rou—
tinely fixed and embedded in paraffin for preparing 5 um serial sections Traditional and confocal im—
munochemicaI detection of viral antigens and heat shock protein 70 were performed to explore the cere—
hral stress response after viral infection.The results showed that HSP70 imm ur~reactivities could be
stably detected in the viral antigen positive neurons,hut not in the viral antigen negative or uninfected
control tissues By confocaI microscopic examination.the H趼,70 and viral antigens were colocolized in
the neuronal cytoplasm .Our result,comparable to our previous findings in human tissues and culture
cells。indicated that Hantavirus infection can induce the expression of H趼,70 in the infected cells。and
HSP70 expresion might he necessary hut not sufficient to keep the cell surviva1.
  Published online: 5 Feb 2001
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