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Virologica Sinica, 16 (2) : 131-134, 2001
Research Article
DNA Immunization of Hepatitis E Virus(HEV)
Institute of Medicai Biology,CAMS/PUMC,Kunming 6501 18.China
Two plasmid constructs,pcE2 and peE3,containing 3’fragment of open reading frame 2
(ORF2,1163 bp)of hepatitis E virus(HEV)and full—length ORF3(369 bp).were injected into bi—
lateral tibiaLs of Swiss mice respectively.for three times(0,2 and 4 weeks)and observed the HEv
IgG by ELIsA HEV IgG was induced after the injection of pcE2 or pcE3 or both,and the percentage
of seraconversion was i00% after two weeks of the third iniection.Compared with injection of either
construct,the antibo dy titers were higher in the group with combined injection of two constructs.
  Published online: 5 Jun 2001
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