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Virologica Sinica, 17 (3) : 202-205, 2002
Research Article
Epitope M apping of Hepatitis C Virus NS3 Antigen from a Phage Peptide Library by Using Imm obilized Specific M onocionai Antibody
Gene Therapy Research Center,Institute of Infectious Diseseas ,Th 302 Hospital 0f PLA,Beijing 100039,China
Using HCV NS3 m onoclonal antibody as selective molecule, a 12 m ar phage peptide library
was biopanned and positive clones were selected by ELISA . com petition assay and DN A sequencing.
Eleven positive clones were chosen for DN A sequencing.From the experim ent and sequencing com par—
ison results,one epitope was confirm ed as m imotope of HCV N S3.HCV N S3 m im otope was obtained
by phage peptide library screening.The result provides a new approach for HCV therapy and vaccine
developm ent.
  Published online: 5 Jun 2002
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