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Virologica Sinica, 17 (4) : 297-303, 2002
The Relationships of Serotypes and Nucleotide Sequences 0f The Dengue viruses Genome
Institute of Virology,Chinese Academy of Preventive Medicine,Beijing 100052,China
The aim of this study was to prove the relationships of serotypes and nucleotide sequences of
the Dengue viruses genome.To this end,the nucleotide sequences of 5 noncoding region,3 一noncod—
ing region,envelope E glycoprotein,nonstructural protein NS1 were aligned correspondingly.W ith
four Dengue viruses phylogenetic groups which were correspo nding to four serotypes each other being
identified,Our results demonstrate that there were no intergenomic recombination observed.The po s—
sibility of intragenomic recombination and the similarity of nucleotide sequences of different Dengue
viruses were analysed.
  Published online: 5 Nov 2002
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