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Virologica Sinica, 18 (3) : 197-200, 2003
Research Article
p53 Expression and Genetic Evidence for Virus Infection in Cervical Carcinoma
1.Department of microbiology,Sun Yat-sen University,Guangzhou 510080
2.1nstitute of l~rology,Medical College, Wuhan University,Wuhan 430071
3.The FirstHospitalofWuhan University
Wuhan 430071,China
Abstract: Wle examined 121 Specimens of exfoliated cells and tissue of cervix for the presence of
肿V一16/18 an d HSV一2 DNA by PCR.At the same time,we analysised 76 specimens from tissue of
cervix for the expression of p53 by immunohistochemical assay.The HPV一16/18 was found in 19
(61.3%)of 31 cervical carcinoma,in 9(22.5%)of 40 chronic cervicitis,in 3(6.O%)of 50 normal
uterine cervix.The positive rate of HSV一2 was 32.3% (10/31),2O.O% (8,4O)and 4.0% (2/50).1 e
mixed infection rate of肿V 16/18 an d HSV一2 was 16.1% in cervical carcinoma.The rates of positive
expression ofp53 was found to have a gradient of crescendo in the tissues of chronic cervicitis.CIN an d
cervical carcinoma.Wle found that cerv ical carcinoma is strongly related witll HPV一16/18 infection.A
synergetic action may OCCUr between HPv an d HSV一2 infections in the oncogenesis of cervical
carcinoma.Th e overepression of p53 appears to be closely associated with the development of cervical
can cer.Th ere is a matter ofclinical significan ce on the prevention an d treatment ofcervical carcinoma.
  Published online: 18 Jun 2003
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