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Virologica Sinica, 18 (4) : 335-339, 2003
Research Article
Genome Comparison Between SARS—associated coronavirus andOther Coronaviruses
Department ofBiological Science&Medical Engineering,Southeast University,Nanfing 210096,China
Abstract:The genome sequences of SARS.associated coronavirus (SARS.COV)were compared witIl
other Coronaviruses.Similar sequences were found by searching biomolecular databases.Sequence
analysis showed that SARS.CoV had similar genomi c organization and structural proteins while
compared with other Coronaviruses.SARS.CoV is related to other known Coronaviruses.But there
were some specific sequences in SARS.CoV genome.Th e virulence of SARS may deftve from
vaxi~ions of ORF l a an d S protein an d the specificity of some nonstructural proteins.Th e result of word
frequency an alysis indicated that SARS.CoV does not closely resemble an y of kn own Coronaviruses.
  Published online: 5 Aug 2003
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