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Virologica Sinica, 18 (6) : 534-537, 2003
Research Article
Antiviral Activity of Algefacient and Anti-inflammatory Against Influenza Virus in vitro and in vivo
TheInstituteof~rology,theMedicalSchool,Wuhan University,Wuhan 430071,China
2. GuilinSanjin Pharmaceutical Co.LTD,GuHin 541004.china
Abstract:To observe the antiviral activity of Algefacient and anti-inflammatory(AI)against influenza
virus,cell culture technique was used in M DCK cells to get virus inhibitory rate an d virus tiler by MTT
assay an d hemagglitination test.Influenza virus infection model was established in mice,to observe the
protection efect to mi ce death ,the inhibitory efect to pulmonary index and pulmonary virus titer.The
results showed that 160ug/mL Algefacient an d anti-inflammatory Can completely inhibit the
proliferation of influenza virus in MDCK cel1.0.1 g&g, 0.5g/kg.1.2g,/kg dosage med cme orally given
for 5 days could significan tly decrease the mortality rate,prolong the living time of infec ted mi ce,
decrease the pulmonary index and pulmonary virus hemagglitination titer(P<O.oi).This efect is
similar to that of virazole at the same dosage leve1.W e conclude that AI is an efective anti-influenz a
virus.compound/n vitro and in vivo.
  Published online: 25 Dec 2003
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