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Virologica Sinica, 18 (6) : 541-543, 2003
Research Article
SARS-CoV Infection Induces Apoptosis of Vero E6
College of Life Sciences,Wuhan University,Wuhan 430072,China
Abstract:To determine if SARS—associated coronavirus(SARS—CoV)induces apoptosis.we studied the
SARS—CoV infected Vero E6 cells by agarose gel electrophoresis.indirect fluorescent staining for
infection an d Hoechst 33528 staining for nuclei,as well as by flow cytometry.It was found that
SARS—C0V infected Vero E6 cells showed typical apoptosis characteristics.Au the typical apoptotic
ceHs were in late—infection period.Most of the cells with cytopathic effect(CPE)showed nuclei witll
condensed chromatin or fragmented into apoptotic bodies.It was suggested that SARS—CoV infection
induces apoptosis of Vero E6.
Key Words: SARS—CoV;  Apoptosis;  Vero E6
  Published online: 25 Dec 2003
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