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Virologica Sinica, 19 (6) : 549-552, 2004
Research Article
Study on Risk Relationship between Hepatitis B Virus and Primary Hepatocellular Carcinoma
1. Department of Hygiene Statistics, Public Health School, Wuhan University, Wuhan 430071, China
2. Wuhan General Hospital of Guangzhou Command of PlA, Wuhan 430070, China
 Correspondence:
(224.66KB)  
Abstract
To understand the relationship between the chronic hepatitis B virus infection and the primary hepatocellular carcinoma (PHC), we adopted the method of retrospection and carried out analysis by comparing the markers of Hepatitis B virus (HBV M) and the result of liver function testing of the 328 cases of PHC and 340 patients with the enteron tumor not suffered from PHC, all of whom were treated in Wuhan general hospital of Guangzhou command of PLA from Jan, 2000 to July, 2003. The results showed that the positive rate of HBsAg in patients with PHC (63.11%) was significantly higher than that in control group with non-PHC (other enteron tumors) (11.47%). In the cases of PHC, the positive rate of the combination of HBsAg, HBeAb and HBcAb was presented 37.2%, which was significantly higher than that of the combination of HBsAg, HBeAg and HBcAb. According to the results of liver function, there was no significant difference between the group which were the combination of HBsAg(+), HBeAb(+), HBcAb(+) and the group which were the combination of HBsAg(+), HBeAg(+) and HBcAb(+) (P>0.05). Hepatic injury in cases of PHC was significantly higher than that in control group of non-PHC (P<0.01). So the chronic hepatitis B virus infection plays extremely important role in PHC’s etiology. The human group who were positive with HBsAg, HBeAb and HBcAb is the PHC’s high-risk group.
Key Words: PHC;  Hepatitis B virus;  Etiology
  Published online: 20 Dec 2004
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