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Virologica Sinica, 19 (6) : 576-581, 2004
Research Article
JDV Tat Transactivate LTR Involves Similar Cytokines as HIV-1 Tat
College of Life Sciences, Nankai University, Tianjin
In order to define if similar cytokines take part in transactivation of Jembrana disease virus and Human immunodeficiency virus-1 Tat protein, two truncated Tat proteins, hTat47 and jTat70, which contained intact activation domains but lacking binding domains, were constructed. We also constructed cyclin T1 and CDK9 eukaryotic expression and antisense plasmids. Overexpression of hTat47 and jTat- 70 both inhibited transactivation of JDV and HIV-1 Tat on HIV-1 or JDV LTR, suggesting that they may involve similar cytokines. Antisense transient assay of cyclin T1 and CDK9 further proved that these cytokines also participated in transactivation of JDV Tat.
Key Words: JDV;  HIV-1;  Tat;  Cyclin T1;  CDK9
  Published online: 20 Dec 2004
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