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Virologica Sinica, 20 (1) : 50-54, 2005
Research Article
Sequencing and Analysis of Complete Sequence of Budgerigar Fledgling Disease Virus Isolated from China
An infectious bursal disease virus (IBDV), isolated from Dongying city in Shandong province, was propagated several generations in SPF embryos and then turned to cell culture. The chickens were immunized by 20th, 21st, and 25th generation cell viruses in different doses at the age of 7 d and 14 d, and then were challenged at the age of 35 d. The titers of antibody to IBDV were detected before inoculation and challenge. According to the titers of antibody against IBDV after inoculation, the morbidity and mortality after challenge, the ratios of immune organ to body weight, the damage of immune organ, the results demonstrated that all the viruses had good immunogenicity when the chickens were vaccinated at 14d with the dose of 3000TCID\-(50) by the primary vaccine, and the chickens gained better immune protection. The 20th generation had durative pathogenicity to chickens when inoculated at 7d and caused immunosuppression to ND immune responses while 21st and 25th had transitory tissue damnification and immunos
  Accepted: 28 Jul 2004  Published online: 20 Jan 2005
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