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Virologica Sinica, 20 (2) : 159-163, 2005
Research Article
Preparation of SV40 Inactivation Vaccine and Immunization of Balb/c Mice
Simian vacuolating virus 40(SV40)belongs to polyoma virus and is a DNA tumor virus.The natural hosts for SV40 are species of Asian macaque monkeys, especially the rhesus (Maccaca mulatta). SV40 can cause widespread infections leading to acutely pathological changes and long-term virus schleping in healthy monkeys. SV40 was shown to be tumorigenic in rodents and was able to transform many types of cells in culture. This work represented the first description of inactivated SV40 by beta-propiolactone and evaluated its immunogenic properties in mice. This work was a primary attempt to tackle SV40 infection and spread has made it ready to further investigate the immunological characteristics of the inactivated virus in monkeys and provided a foundation for vaccine development against SV40.
  Published online: 20 Apr 2005
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