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Virologica Sinica, 20 (4) : 352-356, 2005
Research Article
Immune Response Induced by Recombinant Adenoviruses Expressing Serotype G2 or G3 VP7 of Group A Human Rotavirus in Mice
In order to clarify the feasibility of adenovirus vector-based multivalent genetic engineering vaccine of Rotavirus (RV), we investigated the immune responses induced by the adenoviruses expressing serotype G2 or G3 VP7 of group A rotavirus on the basis of our previous reports. Balb/c mice were immunized with recombinant adenovirus rvAdG2VP7 or rvAdG3VP7, which expressing G2 or G3 type VP7,respectively, via intranasal or oral route for 3 times and serum antibodies, mucosal antibodies as well as the level of related cytokines were determinated. The results demonstrated that immunizing with the adenoviruses expressing serotype G2 or G3 RV VP7 intranasally or orally could induce strong rotavirus-specific immune response in mice, including humoral immunity, cell-mediated immunity, mucosal immunity as well as protective neutralizing antibody. The results also implied that Th2-like response triggered by the immunization is probably the primary response compared to Th1-like response. In summary, this study laid a fo
  Published online: 20 Aug 2005
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