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Virologica Sinica, 21 (2) : 131-135, 2006
Research Article
Analyzing and Sequencing of the Glycoprotein Gene of Rabies Virus Isolates from Guangxi
1. Guangxi General Vererinary Prevention and Quarantine Service , Nanning 530001, China
2. College of Animal Science and Technology, Guangxi University, Nanning 530005, China
 Correspondence:
(162.45KB)  
Abstract
The glycoprotein gene(G) of 12 Rabies virus isolates from different areas in Guangxi were analyzed and sequenced. The results indicated that all rabies virus isolates from Guangxi belong to genotype I and could be divided into 3 groups. GX01, GX08, GX09, GX014, GX091, GX195, GX260 and GXLA strains belong to group Ⅰ. GX219, GX074 and GXBM strains belong to group Ⅱ. GXN119 strain belongs to group Ⅲ. The nucleotide homologies of rabies virus isolates were 97.6% to 99.9% in group Ⅰ and were 98.2% to 99.0% in groupⅡ. The homologies of amino acid sequence were 97.7% to 100% in that the mutations of nucleotide mostly were synonymous mutations, either the main antigenic regions of GI and GⅡ or the main antigenic sites of 36, 263 and 367 amino acid were not any mutative, only the 332 site of valine mutated to isoleucine. The mutations of the deduced amino acid sequence focus on -16, -15, -14, -13, -5, -2, 90, 96, 132, 140, 156, 168, 170, 204, 241, 249, 253, 264, 289, 332, 382, 427, 436, 445, 463 and 474 amino acid on the glycoprotein, all mutations of amino acid has group specificity.
  Published online: 20 Mar 2006
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