Hello guest, Register  |  Sign In
Virologica Sinica, 21 (5) : 510-512, 2006
Brief Reports
Detection of Human Endogenous Retrovirus env Gene in the Blood of Individuals with Schizophrenia by Using Nested RT-PCR
1.State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
2. Renmin Hospital, Wuhan University, Wuhan 430060, China
 Correspondence:
(257.35KB)  
Abstract
The association between transcriptional activation of HERV and the develop- ment of schizophrenia was investigated. Nested RT-PCR was used to detect the preval- ence of HERV env RNA in the PBMCs of individuals with recent-onset of schizophrenia and normal persons from central and southern China. β-actin gene was used as an internal control. HERV env homologous sequences were found in the PBMCs of 8 of 28 (28.6%) individuals with recent-onset schizophrenia, while no env sequences were identified in any of the PBMCs obtained from 24 normal person (P<0.001). The results suggested that transcriptional activation of HERV might be associated with the develop- pment of schizophr- enia in at least some patients.
  Published online: 20 Sep 2006
Home |  Resources |  About Us |  Support |  Contact Us |  Privacy |  Powered by CanSpeed | 
Copyright © 2015 Virologica Sinica. All rights reserved