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Virologica Sinica, 21 (5) : 510-512, 2006
Brief Reports
Detection of Human Endogenous Retrovirus env Gene in the Blood of Individuals with Schizophrenia by Using Nested RT-PCR
1.State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
2. Renmin Hospital, Wuhan University, Wuhan 430060, China
The association between transcriptional activation of HERV and the develop- ment of schizophrenia was investigated. Nested RT-PCR was used to detect the preval- ence of HERV env RNA in the PBMCs of individuals with recent-onset of schizophrenia and normal persons from central and southern China. β-actin gene was used as an internal control. HERV env homologous sequences were found in the PBMCs of 8 of 28 (28.6%) individuals with recent-onset schizophrenia, while no env sequences were identified in any of the PBMCs obtained from 24 normal person (P<0.001). The results suggested that transcriptional activation of HERV might be associated with the develop- pment of schizophr- enia in at least some patients.
  Published online: 20 Sep 2006
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