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Virologica Sinica, 21 (6) : 541-545, 2006
Research Article
H and N Gene Variation Rate of Measles Virus Strain in China
1. The Affiliated Children Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China
2.Zhejiang Center for Disease Prevention and Control, Hangzhou, Zhejiang, 310009, China
The gene sequences of the Hemagglutinin and Nucleoprotein were downloaded from GenBank. Bioedit7.0 softwere was used to pairwise these sequences and to construct a phylogenetic tree to analyze the variation rate of measles virus strains. The results demonstrated that variation rate of hemagglutinin gene was 1.33´10-3 in the recent 10 years, which was about 1.4-fold higher than in the former 30 years. The variation rate of nucleoprotein gene was 1.90´10-3 in the recent 10 years, which was about 1.8-fold higher than in the former 30 years. These findings suggest that monitoring the variation of measles virus should be emphasized because of the increasing variation rate in the recent 10 years.
Key Words: Measles;  Gene;  Variation rate
  Published online: 20 Nov 2006
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