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Virologica Sinica, 21 (6) : 546-550, 2006
Research Article
Functional Analysis of SR-15 Protein of Human Fibroblast Induced by HSVⅠInfection
Institute of Medical Biology, Chinese Academy of Medical Science /Peking Union Medical College, Kunming 650118, China
The binding of HSVⅠ to receptors of human fibroblast initiates viral infection and induces the cells to express specific proteins. SR-15, one of these proteins, was identified to interact with certain zinc finger proteins containing KRAB domain through binding zinc finger domain in yeast trap system. This interaction impacts the transcriptional repression of ZNF268, which is one of this type of zinc finger proteins in cells.
  Published online: 20 Nov 2006
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