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Virologica Sinica, 22 (3) : 212-217, 2007
Research Article
Differences in Variation of Human Immunodeficiency Virus Type 1 Sequences from Henan and Shanghai Regions of China
1.Department of Infectious Diseases,Fudan University Huashan Hospital, Shanghai 200040,China
2. Department of Infectious Diseases, the Sixth People’s Hospital, Hangzhou 310014, China
3.Division of Infectious Diseases, Department of Medicine
Tennessee 37232, USA
4. Departments of Pathology
Tennessee 37232, USA
5. Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Illegally paid blood donation was a risk factor for HIV acquisition exclusively in Henan and Hubei Provinces of China, and not in Shanghai. Nucleotide sequences in the gag and env genes of HIV-1 were compared between isolates from Henan and Shanghai regions of China to test whether an expected higher degree of a common source of infections from this unique blood donation transmission risk would be evident as decreased variation among Henan isolates in an exploratory cross-sectional analysis. Among 38 isolates studied, 23 of 23 (100%) from Henan and 8 of 15 (54%) from Shanghai were subtype B. In addition, fewer sequence differences were found in gp41 of subtype B isolates from Henan than from Shanghai isolates. Further studies with additional controls are therefore warranted to confirm the role of the degree of a common source of infections in differences in HIV variation across populations.
  Published online: 20 Jun 2007
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