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Virologica Sinica, 22 (3) : 248-255, 2007
Pathogenesis and Associated Diseases of Kaposi’s Sarcoma-associated Herpesvirus
State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences,Wuhan 430071,China
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the primary etiological agent of Kaposi’s sarcoma, primary effusion lymphoma and muticentric Castleman’s disease. In common with the other herpesviruses, KSHV exhibits both latent and lytic life cycles, both of which are characterized by distinct gene expression profiles and programs. KSHV encodes proteins which play essential roles in the inhibition of host adaptive and innate immunity, the inhibition of apoptosis, and the regulation of the cell cycle. KSHV also encodes several proteins which have transforming and intrcellular signalling activity.
  Published online: 20 Jun 2007
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