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Virologica Sinica, 22 (4) : 287-293, 2007
Research Article
Expression and Immunoreactivity of a Human Group A Rotavirus Vp4
Institute of Medical Biology of Chinese Academy Medical Sciences &Peking Union Medical College, Kunming 650118, China
Rotavirus capsid protein Vp4 plays an important role in the virus adhering and entering the cells. In this study, a Vp4 gene cloned from a rotavirus strain TB-Chen was highly expressed in E.coli BL21 (DE3). The results of the Western blot showed that the protein possesses specific immuno-reactivities and can be specifically recognized by guinea pig antibodies against rotavirus strain SA11 or Wa. Some Vp4 dimers were formed during renaturation. These data obtained from this study provide a strong basis for further study on the structure and function of the Vp4.
  Published online: 20 Aug 2007
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