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Virologica Sinica, 22 (6) : 451-461, 2007
Novel Antiviral Agents Targeting HIV Entry and Transmission
1. Center for Infection, Department of Cellular and Molecular Medicine, St George’s University of London, London SW17 0RE, UK
2. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
Studies of the mechanism of HIV entry and transmission have identified multiple new targets for drug development. A range of inhibitors have demonstrated potent antiretroviral activity by interfering with CD4-gp120 interaction, coreceptor binding or viral-cell fusion in preclinical and clinical studies. One of these agents, fusion inhibitor enfuvirtide, is already in clinical use. Here we review the progress in the development of specific entry inhibitors as novel therapeutics. The potential of entry inhibitors as topical microbicides to block HIV transmission is also discussed.
  Published online: 25 Dec 2007
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