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Virologica Sinica, 23 (2) : 146-151, 2008
Biological Effects of HBV X Protein on Hepatocellular Carcinogenesis in Association with Cellular Factors*
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
The X protein (HBx) of Human hepatitis B virus (HBV) acts as an indirect transcriptional transactivator to regulate the expression of many viral and cellular genes, as well as playing a critical role in pathogenesis and the development of Hepatocellular carcinoma (HCC). Here we described the biological effects of HBx in association with four cellular factors, including inflammatory factors (COX-2 and iNOS), oncoprotein (Ras), and a newly identified tumor suppressor (YueF). The characteristics of these effectors, which might be associated with hepatocellular carcinoma, are also discussed.
  Published online: 25 Apr 2008
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