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Virologica Sinica, 23 (2) : 93-99, 2008
Review
Advances in Research on Hepatitis B Virus DNA Integration
Institute of Liver Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China
 Correspondence:
(179.11KB)  
Abstract
Since HBV DNA integration was discovered for the first time in 1980, various methods have been used to detect and study it, such as Southern Blot, in situ hybridization, polymerase chain reaction and so on. HBV DNA integration is thought to be random on the whole although some hot spots of integration were described by some researchers, one of which might be the repetitive sequences of the genomic DNA. Besides, DNA damage, especially double-strand breaks could promote HBV DNA integration into host genome. HBV DNA integration into cells may damage the stability of the genome, cause DNA rearrangement, promote DNA deletion and induce the formation of HCC.
  Published online: 25 Apr 2008
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