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Virologica Sinica, 23 (6) : 399-405, 2008
Review
The Herpes Simplex Virus Type 1 Multiple Function Protein ICP27*
State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
Correspondence: 
(226.07KB)
Abstract
The herpes simplex virus type 1 (HSV-1) infected-cell protein 27 (ICP27) is an essential, highly conserved protein involved in various steps of HSV-1 gene regulation as well as in the shut-off of host gene expression during infection. It functions primarily at the post-transcriptional level in inhibiting precursor mRNA splicing and in promoting nuclear export of viral transcripts. Recently, many novel functions performed by the HSV-1 ICP27 protein were shown, including leptomycin B resistance, inhibition of the typeⅠinterferon signaling, regulation of the viral mRNA translation and determining the composition of HSV-1 virions.
Key Words: Herpes simplex virus type 1 (HSV-1); Infected-cell protein 27（ICP27）; Nuclear export; Leptomycin B (LMB); Interferon (IFN)
Published online: 5 Dec 2008
