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Virologica Sinica, 23 (6) : 394-398, 2008
Molecular Modification of a HSV- 1 Protein and Its Associated Gene Transcriptional Regulation
Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 379 Jiao Ling Road, Kunming 650118, China
The molecular modifications of Herpes Simplex Virus Type I (HSV-1) proteins represented by acetylation and phosphorylation are essential to its biological functions. The cellular chromatin-remodeling/ assembly is involved in HSV-1 associated gene transcriptional regulation in human cells harboring HSV-1 lytic or latent infections. Further investigation on these biological events would provide a better understanding of the mechanisms of HSV-1 viral gene transcriptional regulation
  Published online: 5 Dec 2008
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